The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Top Cited Papers
- 1 February 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 7 (2) , 156-167
- https://doi.org/10.1038/nrd2466
Abstract
The inorganic anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism. However, recent studies show that these supposedly inert anions can be recycled in vivo to form NO, representing an important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular in hypoxic states. This Review discusses the emerging important biological functions of the nitrate-nitrite-NO pathway, and highlights studies that implicate the therapeutic potential of nitrate and nitrite in conditions such as myocardial infarction, stroke, systemic and pulmonary hypertension, and gastric ulceration.Keywords
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