COMPARISON OF EFFECTS OF R-(-)-2-AMINO-1-(2,5-DIMETHOXY-4-METHYLPHENYL) PROPANE (DOM), R-(-)-2-AMINO-1-(2,5-DIMETHOXY-4-METHYLPHENYL) BUTANE (BL-3912A) AND 5-HYDROXYTRYPTAMINE ON NON-INNERVATED VASCULAR SMOOTH-MUSCLE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (3) , 449-454
Abstract
Isolated strips of sheep umbilical arteries contracted in the presence of R-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL3912A). These contractions faded over a 1 h period and at this time BL3912A antagonized contractions to R-(-)-DOM, 5-hydroxytryptamine (5-HT) but not to angiotensin. The initial contraction produced by BL3912A was antagonized by cinanserin, a 5-HT antagonist. BL3912A can be classified as a partial agonist of 5-HT receptors in sheep umbilical arteries.

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