Enantioselective Borohydride Reduction Catalyzed by Optically Active Cobalt Complexes
- 11 September 2003
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 9 (18) , 4485-4509
- https://doi.org/10.1002/chem.200304794
Abstract
The highly enantioselective borohydride reduction of aromatic ketones or imines to the corresponding alcohols was developed in the presence of a catalytic amount of an optically active cobalt(II) complex catalyst. This enantioselective reduction is carried out using a precisely premodified borohydride with alcohols such as tetrahydrofurfuryl alcohol, ethanol and methanol. High optical yields are obtained by choosing the appropriate alcohol as modifiers and a suitable β‐ketoiminato ligand of the catalyst. The enantioselective borohydride reduction has been successfully applied to the preparation of optically active 1,3‐diols, the stereoselective reduction of diacylferrocenes, and dynamic and/or kinetic resolution of 1,3‐dicarbonyl compounds.Keywords
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