Reduction of Intercellular Adhesiveness of Chick Heart Cells by Herpes Simplex Viruses 1 and 2

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Abstract
Infection with herpes simplex viruses type 1 or 2 prevented the aggregation of 7-day-old chick heart cells into smooth, spheroidal, spontaneously beating aggregates. Virus infection also caused a loosening of peripheral cells in aggregates formed from initially uninfected cells. Measurements of rate of attachment of labeled single heart cells to a monolayer of like cells (homotypic), to [human laryngeal carcinoma] HEp-2 cells (heterotypic), or to plastic substrate (nonspecific adhesion) indicated that virus infection caused a significant but differential loss of homotypic and nonspecific adhesiveness, but no alteration in heterotypic attachment rates. Apparently, those cell surface changes induced by viruses which are related to cell adhesion can be quantified by techniques measuring attachment rates.

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