The Influence of Acute Stress on the Response of Rabbits to Intravenous Endotoxin

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Abstract
Immature rabbits were subjected to an acute stress period in a modified Noble-Collip drum, alone and in conjunction with an intravenous injection of E. coli endotoxin. The lethal effects and incidence and severity of the morphologic changes were appreciably greater in the animals given endotoxin in association with stress than in those subjected to rotation alone. The similarity of these lesions to those produced by two properly spaced injections of endotoxin is discussed. The results of the study support the hypothesis that adrenal gland hormones participate in the effects produced by endotoxin.