Molecular Defects in Interactions of Platelets with the Vessel Wall

Publisher Website
Google Scholar
Abstract
EARLY in this century, it was clearly demonstrated that blood platelets are essential for hemostasis,1 and shortly thereafter the first report appeared demonstrating that a congenital hemorrhagic disease can result from abnormal platelet function.2 Since that time, descriptions of many additional disorders have greatly added to our understanding of the role of platelets in normal hemostasis.3 4 5 6 Analytical techniques developed during the past decade have helped both to identify the molecular abnormalities causing these disorders and to define the mechanisms of platelet-vessel-wall interactions. It has been demonstrated that platelet function requires the presence of specific receptors on the platelet surface that . . .