Total synthesis of the antileukaemic lignan (±)-steganacin

1 January 1977

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1

Vol. 14 (14) , 1674-1681
https://doi.org/10.1039/p19770001674

Abstract

A synthetic route to the antileukaemic lignan (±)-steganacin (1) is described from the readily available piperonal and 3,4,5-trimethoxyphenylacetic acid. Diastereoisomerism encountered in a number of precursors has been ascribed unambiguously to the presence of the bridged biphenyl system (atropisomerism).

Keywords

TOTAL SYNTHESIS