Persistent oligemia of rat cerebral cortex in the wake of spreading depression
- 1 November 1982
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 12 (5) , 469-474
- https://doi.org/10.1002/ana.410120510
Abstract
Cerebral blood flow during and after spreading depression (SD) was studied in rat brain by quantitative autoradiography. The rise of cortical blood flow during SD was followed by 20 to 25% reduction belwo normal after SD, lasting at least an hour. Blood flow in the putamen, thalamus, and hippocampus did not change at any time during or after SD. Previous measurements of cerebral blood flow in humans showed that migraine attacks may be accompanied by wavelike spreading oligemia (Olesen et al, 1981). We speculate that the spreading oligemia of migraine may be a phenomenon physiologically related to the present finding of an oligemia after SD.Keywords
This publication has 20 references indexed in Scilit:
- Blood‐Brain Glucose Transfer in Spreading DepressionJournal of Neurochemistry, 1981
- Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraineAnnals of Neurology, 1981
- Rapid simultaneous determination of regional blood flow and blood‐brain glucose transfer in brain of rat1Acta Physiologica Scandinavica, 1980
- Extracellular potassium and blood flow in the post-ischemic rat brainPflügers Archiv - European Journal of Physiology, 1980
- Principles and methods for the quantitative determination of feulgen stained DNA with the television texture analysis system (TAS)Histochemistry and Cell Biology, 1979
- Platelet aggregation and vasoconstriction in undamaged microvessels on cerebral surface adjacent to brain traumatized by a penetrating needleMicrovascular Research, 1978
- Extracellular Potassium Concentration in Juvenile and Adult Rat Brain Cortex during AnoxiaActa Physiologica Scandinavica, 1977
- Responses of electrical potential, potassium levels, and oxidative metabolic activity of the cerebral neocortex of catsBrain Research, 1975
- The relation of dehydration of the brain to the spreading depression of LeaoElectroencephalography and Clinical Neurophysiology, 1950
- The effect of potassium on the glucolysis of brain tissue with reference to the Pasteur effectBiochemical Journal, 1935