Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. III. N-Cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide and related compounds.

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Abstract
A series of N,N-disubstituted-.omega.-(1,2-dihydro-2-oxoquinolyloxy)alkanecarboxamides was synthesized and tested for inhibitory activity towards collagen- and ADP-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of .omega.-(1,2-dihydro-2-oxoquinolyloxy)alkanoic acid and various amines by the mixed anhydride method. Among them, N-cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide (IVa1) had the most potent inhibitory activity. The structure-activity relationships are discussed.

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