Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule.
- 20 December 1994
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 91 (26) , 12976-12979
- https://doi.org/10.1073/pnas.91.26.12976
Abstract
We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site" capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.Keywords
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