Allergic angiitis and granulomatosis. Prolonged remission induced by combined prednisone--azathioprine therapy

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Abstract
Two patients with acute, rapidly progressive generalized vasculitis initially had symptoms of asthma. Progressive increase in severity of asthma was followed by systemic disease, including pulmonary infiltrative disease, mononeuritis multiplex and abdominal pain. Examination of the tissues demonstrated vasculitis with eosinophilia, and clinically both cases appeared in a near terminal state. High-dose prednisone did not induce a remission. The lesions of mononeuritis multiplex progressed after initiation of high-dose prednisone. The addition of azathioprine to the regimen was followed by a gradual and then complete remission of clinical and laboratory abnormalities, except for some residual nerve damage and asthma of varying severity in the 2 patients. These 2 patients, whose cases are classified as the allergic granulomatosis variant of polyarteritis nodosa, have had a remission of 7 and almost 2 yr, respectively, after combined prednisone-azathioprine therapy.

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