COST OF CASE-CONTROL STUDIES

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Abstract
A financial review of five case-control studies concerning the relationship of birth control methods to the occurrence of disease was conducted. The review had two major objectives: first, to identify costs associated with the planning, conduct and analysis of case-control studies; second, to assess whether sample size determination based on optimal allocation would have resulted in a significant reduction in cost. The data collection phase represented about 75% of the total cost of a study, whereas the costs of planning and analysis were roughly 10% and 15% of total cost respectively. The typical cost in mid-1970s dollars was from $100–$200 per subject. Evaluation of an optimal allocation procedure based on the relative cost of cases and controls demonstrated that such a method was likely to reduce total study cost by at most 2 per cent.

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