In vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid

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Abstract
The in vitro activity of the new macrolide azithromycin and erythromycin againstHaemophilus ducreyi, Gardnerella vaginalis, Bacteroides spp. andMobiluncus spp. was compared.Gardnerella vaginalis, Mobiluncus spp. andHaemophilus ducreyi were highly susceptible to both agents but azithromycin was more effective overall against all three groups of organisms. The activity of both antibiotics againstBacteroides spp. varied greatly, but azithromycin was again more active. Collectively, 62 % of allBacteroides strains were susceptible to erythromycin (MIC 1 mg/1) and 74 % were susceptible to azithromycin.