Mechanisms Involved in Cardiac Enlargement and Congestive Heart Failure Development after Acute Myocardial Infarction
- 1 January 1992
- journal article
- clinical trial
- Published by S. Karger AG in Cardiology
- Vol. 81 (4-5) , 213-220
- https://doi.org/10.1159/000175807
Abstract
For 3 months, we followed up 40 patients with acute myocardial infarction, 20 were randomly assigned to treatment with captopril and 20 to placebo, to elucidate mechanisms inducing left ventricular volume enlargement and development of congestive heart failure. Echocardiographic follow-up could be obtained in 28 patients, 11 of whom showed more than a 10% increase in left ventricular systolic and/or diastolic volumes (captopril n = 3/15, placebo n = 8/13, p = 0.05). Volume increase was significantly associated with an impairment in exercise capacity (VO2max in patients with vs. without volume enlargement 24.7 ± 1.7 vs. 29.5 ± 1.9 ml O2/kg/min; pThis publication has 0 references indexed in Scilit: