Clinical Evaluation of 99mTc Diaminocyclohexane, a Renal Tubular Agent with Cationic Transport: Results in Healthy Human Volunteers
- 1 January 1993
- journal article
- clinical trial
- Published by S. Karger AG in Nephron
- Vol. 65 (2) , 294-298
- https://doi.org/10.1159/000187491
Abstract
As alternatives to anionically transported hippuran, structure distribution experiments on a series of 99mTc-labelled primary substituted ethylene diamine compounds led to selection of 99mTc diaminocyclohexane (DACH) for clinical evaluation, 99mTc DACH, a cation with the structure trans-[O2(DACH)299mTc]+ is prepared by mixing 50 μmol DACH, 1 μmol stannous tartarate and 500 MBq of 99mTc. Seven normal volunteers underwent renal imaging and clearance studies using 150 MBq of 99mTc DACH and 1 MBq of 125I hippuran simultaneously. The images with 99mTc DACH revealed good uptake and excretion. The mean ± 2 SD values of parenchymal and whole-kidney transit time indices and mean parenchymal transit time were 46 ± 33, 75 ± 64 and 141 ± 51 s, respectively, similar to mercaptoacetyl triglycine. The mean clearance of 99mTc DACH was found to be 163 ml/min (SD = 32). Following cationic blockade with 900 mg oral thiamine, significant reduction (p < 0.001) in DACH clearance was noted, but hippuran clearance remained unaltered. The results support the hypothesis that 99mTc DACH is transported cationically.Keywords
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