Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs
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Open Access
- 12 September 2007
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (37) , 9817-9823
- https://doi.org/10.1523/jneurosci.2707-07.2007
Abstract
Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre constructs for 10 genes (Chat,Th,Slc6a4,Slc6a2,Etv1,Ntsr1,Drd2,Drd1,Pcp2, andCmtm5) produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.Keywords
This publication has 22 references indexed in Scilit:
- Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease modelsNature Neuroscience, 2006
- Transgenic expression of Cre recombinase from the tyrosine hydroxylase locusGenesis, 2004
- Talking about a RevolutionDevelopmental Cell, 2004
- Cerebellar granule cell Cre recombinase expressionGenesis, 2003
- Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kγ Origin of ReplicationGenome Research, 2002
- Bac to the future: The use of bac transgenic mice for neuroscience researchNature Reviews Neuroscience, 2001
- Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsomeNature Biotechnology, 1997
- Inducible Gene Targeting in MiceScience, 1995
- Evidence for transient expression of tyrosine hydroxylase immunoreactivity in the mouse striatum and the effect of colchicine.ACTA HISTOCHEMICA ET CYTOCHEMICA, 1991
- D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal NeuronsScience, 1990