CONCANAVALIN A‐INDUCED ACTIVATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS MEMORY LYMPHOCYTES INTO SPECIFICALLY CYTOTOXIC T CELLS

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Abstract
When spleen cells, which have been primed to Lymphocytic Choriomeningitis (LCM) virus during a primary infection several months previously, are stimulated in vitro with Con A, highly specific secondary cytotoxic effector cells are generated. The degree of cytotoxicity revealed by such Con A‐stimulated cells is higher than that of non‐incubated spleen cells harvested nine days following the primary infection, and the effect is totally inhibited by anti‐theta serum plus complement treatment of the effector cells immediately before the cytotoxic test.