Complement Components of Paired Mother-Cord Sera.

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Abstract
The lower total hemolytic activity of complement in cord serum, compared to maternal, is reflected in a parallel decrease in the 4 major components. The failure to detect anti-complementary activity in the cord sera precluded invoking this explanation for the above observation. Serum deficient in the 4th component of complement was prepared by continuous-flow paper electrophoresis and served as an effective R4 reagent. Since, by this method, 3 of the 4 components were found to migrate as a peak in the [alpha]-[beta] globulin region, a relationship may exist between the lower hemolytic activity and the reduced concentration of these globulins in cord sera.