Postprandial intestinal hyperemia: role of bile salts in the ileum

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Abstract
In an autoperfused dog ileum preparation, arterial pressure, venous outflow pressure, blood flow and arteriovenous O2 difference were measured while bile and bile salt solutions, at physiological concentrations, were placed in the lumen. Intraluminal placement of endogenous bile, synthetic bile or bile salt solutions increased ileal blood flow (99 .+-. 10, 94 .+-. 20 and 104 .+-. 17%, respectively), and O2 uptake (30 .+-. 5, 36 .+-. 9 and 28 .+-. 5%, respectively). Endogenous bile pretreated with cholestyramine, a bile salt-sequestering resin, did not alter ileal blood blow, yet increased ileal O2 uptake by 11 .+-. 3%, a response similar to that observed while Tyrode''s solution (the vehicle) was in the lumen. Intra-arterial infusion of bile salts increased ileal blood flow in a dose-dependent manner, while not significantly altering ileal O2 uptake. Bile salts apparently play an important role in the functional (postprandial) hyperemia in the ileum by directly dilating the ileal vasculature and enhancing ileal metabolism during their active absorption.

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