Stimulation by Phagocytosis of the Deiodination of L-Thyroxine in Human Leukocytes
- 2 June 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4038) , 1039-1041
- https://doi.org/10.1126/science.176.4038.1039
Abstract
Intact human leukocytes actively deiodinate L-[1311] thyroxine, producing mainly inorganic 1311 and chromatographically immobile 1311-labeled origin material. When phagocytosis is induced, the deiodination is enhanced, a suggestion that deiodination in mediated by a peroxidase-hydrogen peroxide system. l-Thyroxine can serve as a source of iodine for iodination reactions within the leukocyte.Keywords
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