Induced Protein and Deciduoma Formation in Rat Uterus

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Abstract
In the pregnant rat in which deciduomas were induced by injection of arachis oil into the uterus, the induced protein (IP) synthesis is greatly increased in the deciduomas. A similar increase was obtained in deciduomas induced in progesterone-maintained ovariectomized animals. The increased synthesis in the pregnant animals was not correlated either with circulating estradiol levels or the concentration of nuclear estradiol receptor. Synthesis was generally correlated with the cellular mitosis degree in the uterus. Apparently IP synthesis is suppressed in the uterus on day 5 of pregnancy, but is released from suppression by decidualization initiation. IP may be involved in uterine cell division.

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