Metabolism of 2,2′,5,5′-tetrachlorobiphenyl: formation of mono- and bis-methyl sulphone metabolites with a selective affinity for the lung and kidney tissues in mice
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 12 (1) , 1-7
- https://doi.org/10.3109/00498258209052449
Abstract
Distribution in mice of [the environmental pollutant] 2,2'',5,5''-tetrachloro[14C]biphenyl was studied by autoradiography. Radioactivity was specifically localized in the bronchial epithelium, lung parenchyma, kidney cortex and adipose tissue. Bis(methylsulphonyl)-2,2''-5,5''-tetrachlorobiphenyl, an unknown metabolite of 2,2'',5,5''-tetrachlorobiphenyl, was identified in lung, kidney and liver of mice; 3- and 4-methylsulfonyl-2,2'',5,5''-tetrachlorobiphenyl in the liver was 1:12 after 12 days. A lower ratio in lung and kidney indicated a high affinity of these tissues for the 4-methyl isomer.This publication has 24 references indexed in Scilit:
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