1-Acyl-indoles. II. A New Syntheses of 1-(p-chlorobenzoyl)-5-methoxy-3-indolylacetic Acid and Its Polymorphism

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Abstract
1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indoleacetic acid, a potent antiinflammatory drug, was directly prepared from N1-(p-chlorobenzoyl)-p-methoxyphenyl-hydrazine hydrochloride and levulinic acid in excellent yield by the new method. The recrystallization of l-(p-chlorobenzoyl)-2-methyl -5-methoxy-3-indoleacetic acid from solvents gave crystals of polymorphism [alpha], [beta]-, and gamma-types.