Synthesis and properties of oxytocin analogues with high and selective natriuretic activity
- 1 January 1982
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 47 (9) , 2540-2560
- https://doi.org/10.1135/cccc19822540
Abstract
Deamino-6-carba-oxytocin analogues with modified aromatic amino acid in the position 2 were prepared by stepwise peptide synthesis in solution and cyclization in the last step. Some of the prepared analogues exhibit high and/or specific natriuretic activity. Structural requirements for this type biologic activity are discussed.Keywords
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