Hybridization Properties of the 5-Methyl-isocytidine/isoguanosine Base Pair in Synthetic Oligodeoxynucleotides

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Abstract
The hybridization properties of the 5-methyl-isocytidine/isoguanosine base pair in synthetic oligodeoxynucleotides have been investigated. The 5-methyl-isocytidine/isoguanosine base pair has been determined to be isoenergetic with the cytidine/guanosine, and each base can effectively discriminate mismatches.