Carcinogenicity of 3′ -hydroxymethyl-N, N-dimethyl-4-aminoazobenzene in rat liver
- 1 June 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (6) , 533-535
- https://doi.org/10.1093/carcin/1.6.533
Abstract
Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3' -hydroxymethyl-N, N-dimethyl-4-aminoazobenzene (3' -CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3' -Me-DAB in the diet). The oral administration of 3' -CH2OH-DAB for 3 months resulted in a high incidence of liver tumors at 6 months and the 1 month feeding also caused the development of liver tumors. Histologically, the tumors were cholangiocellular carcinomas and hepatocellular carcinomas. The development of tumors in other sites was not seen. Consequently, 3' -CH2OH-DAB, a recently identified metabolite of 3' -Me-DAB, is a potent hepatocarcinogen.Keywords
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