Direct Evidence for a Colchicine-Induced Impairment in the Mobility of Membrane Components
- 14 December 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 182 (4117) , 1136-1138
- https://doi.org/10.1126/science.182.4117.1136
Abstract
Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.Keywords
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