SUPPRESSION OF CYTOTOXIC RESPONSE TO HISTOINCOMPATIBLE CELLS .1. EVIDENCE FOR 2-TYPES OF LYMPHOCYTE-T-DERIVED SUPPRESSORS ACTING AT DIFFERENT STAGES IN THE INDUCTION OF A CYTOTOXIC RESPONSE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 122  (3) , 737-746
Abstract
Spleen and thymus cell populations from normal or allograft tolerant mice were cultured for 5 days with specific alloantigens and examined for their reactivity in 3 assay systems. No consistent correlation were observed between the production of cytotoxic T [thymus-derived] cells (CTL) in these cultures and the ability of such cultured cells to inhibit specifically a CML [cell-mediated lympholysis] response from fresh normal spleen cells directed to the priming alloantigens. Suppressor cells measured in this latter assay were apparently distinct from those able to inhibit the production of cytotoxic lymphocyte precursors (CTLp) from bone marrow stem cells in lethally irradiated bone marrow-protected mice. Velocity sedimentation experiments confirmed that both the precursor and effector cells for the 2 suppressor systems were physically separable, and were distinct from CTLp or CTL, respectively. Precursor cells for the 2 suppressor systems investigated belong to the short-lived cortical thymus cell population.

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