Postoperative Studies of Adrenal Function in Primary Aldosteronism1

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Abstract
During the first month after removal of a unilateral aldosterone-produclng adenoma, Na conservation is poor and restriction of Na intake may result in adrenal insufficiency. The excretion of aldos-terone is reduced and does not increase in response to stimulation by administration of corticotropin, angiotensin, and by restriction of Na intake. Chronic hypervolemia in patients with primary aldosteronism can result in selective suppression of the ability of the adrneal gland to secrete normal amounts of aldosterone immediately after removal of an aldosterone-secreting tumor.