Gastroesophageal Reflux in Obese Patients Is Not Reduced by Weight Reduction
- 1 January 1996
- journal article
- clinical trial
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 31 (11) , 1047-1051
- https://doi.org/10.3109/00365529609036885
Abstract
The present study tested the hypothesis that weight reduction improves the subjective and objective manifestations of gastroesophageal reflux. Twenty obese patients with gastroesophageal reflux as shown by 24-h pH measurement and with symptoms requiring daily medication were studied. The patients were randomized into a group (A) treated with very low-caloric diet (VLCD) and a control group (B). Objective measurements were repeated after 6 months. Group B was then treated with VLCD and reexamined. Patients in group A lost 10.8 +/- 1.4 kg whereas group B gained 0.6 +/- 0.7 kg (P < 0.001). There was no reduction in reflux according to pH measurement. Furthermore, there were no significant changes in reflux symptoms. After VLCD treatment, group B lost 9.7 +/- 1.6 kg, but reflux indicators remained unchanged. All patients except one in group B remained dependent on daily anti-reflux medication. Weight reduction does not improve the subjective or objective manifestations of reflux.Keywords
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