Evidence Against the Role of K+ in the Shut-off of Protein Synthesis by Vesicular Stomatitis Virus
- 1 June 1978
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 39 (3) , 551-554
- https://doi.org/10.1099/0022-1317-39-3-551
Abstract
Intracellular K+ ion concentration and transport were measured in L cells infected with wild type VSV, which rapidly inhibits total protein synthesis in infected cells, and with a mutant, R1, defective in this function. No alterations in intracellular K+ ion concentration or transport were observed until late in infection and the late changes seen were similar for both viruses. Thus the inhibition of total protein synthesis by VSV cannot be ascribed to virus induced changes in host K+ ion concentration.This publication has 5 references indexed in Scilit:
- Analysis of VSV mutant with attenuated cytopathogenicity: Mutation in viral function, P, for inhibition of protein synthesisCell, 1977
- Alteration of the Intracellular Energetic and Ionic Conditions by Mengovirus Infection of Ehrlich Ascites Tumor Cells and Its Influence on Protein Synthesis in the Midphase of InfectionJournal of Virology, 1977
- Control of protein synthesis in human fibroblasts by intracellular potassium*1Experimental Cell Research, 1977
- BIOCHEMICAL BASIS FOR ALTERATIONS IN STRUCTURE AND FUNCTION OF HELA CELLS INFECTED WITH NEWCASTLE DISEASE VIRUSThe Journal of Experimental Medicine, 1961
- PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSESThe Journal of Experimental Medicine, 1954