ONE-YEAR ENZYME-LINKED IMMUNOSORBENT ASSAY FOLLOW-UP OF HUMAN INTERLEUKIN FOR Da CELLS/LEUKEMIA INHIBITORY FACTOR IN BLOOD AND URINE OF 22 KIDNEY TRANSPLANT RECIPIENTS
- 27 December 1994
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 58 (12) , 1190-1194
- https://doi.org/10.1097/00007890-199412000-00009
Abstract
The cytokine human interleukin for Da cells/leukemia inhibitory factor (HILDA/LIF) exerts multiple biological effects in vitro. In mice, high circulating levels of HILDA/LIF induce a wide range of pathophysiological events, some of them closely involved with immunological and inflammatory responses. Using a sandwich ELISA recognizing the natural human HILDA/LIF molecule with a threshold of 50 pg/ml in urine and 150 pg/ml in plasma, we monitored the urine and plasma HILDA/LIF levels of 22 patients in their first year after a kidney transplant. HILDA/LIF urine excretion is increased during acute rejection, and infections also trigger heavy HILDA/LIF plasma concentrations or urine excretion. In addition, this study raises the question of HILDA/LIF involvement in post-kidney-transplant phenomena such as hypercalcemia, osteoporosis, or the reversal of anemia.Keywords
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