Isolation and partial characterization of a growth inhibitor ofParacoccidioides brasiliensis
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 20 (2) , 159-168
- https://doi.org/10.1080/00362178285380231
Abstract
A lethal diffusible metabolite excreted by the yeastlike form of Paracoccidioides brasiliensis was isolated, purified, and partially characterized. The chemical structure of this metabolite suggested a relation to the phenol or benzoic acid families. The lethal effect on P. brasiliensis could not be attributed specifically to interference with synthesis of macromolecules, but probably through protein denaturation. This lack of specificity discounts its possible use as an antibiotic.Keywords
This publication has 10 references indexed in Scilit:
- Growth curves of the yeast-like form ofParacoccidioides brasiliensisMedical Mycology, 1975
- Recent Developments of Antibiotic Research and Classification of Antibiotics According to Chemical StructurePublished by Elsevier ,1974
- Growth curves and nucleic acids content of mycelial and yeast-like forms of Paracoccidioides brasiliensisMycopathologia, 1970
- Phenethyl Alcohol and Tryptophol: Autoantibiotics Produced by the Fungus Candida albicansScience, 1969
- CHEMICAL ASPECTS OF COMPENSATORY RENAL HYPERTROPHY1965
- Protein Determination of Large Numbers of SamplesAnalytical Chemistry, 1959
- Determination of Dextran with AnthroneAnalytical Chemistry, 1953
- A MICROCHEMICAL DETERMINATION OF DESOXYRIBONUCLEIC ACIDJournal of Biological Chemistry, 1952
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951