Analysis of the aromatase cytochrome P450 gene in human breast cancers
- 1 December 1994
- journal article
- Published by Bioscientifica in Journal of Molecular Endocrinology
- Vol. 13 (3) , 331-337
- https://doi.org/10.1677/jme.0.0130331
Abstract
Aromatase activity may be detected in most, but not all, breast cancers, and in certain tumours there appears to be decreased sensitivity to the aromatase inhibitor 4-hydroxyandrostenedione (4-OHA). The aims of the present study were to measure aromatase activity, and its sensitivity to 4-OHA, in breast tumours, and to examine the CYP19 gene encoding the aromatase cytochrome P450 (P450arom) for the presence of mutations.Keywords
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