Macroglobulin Structure: Homology of Mu and Gamma Heavy Chains of Human Immunoglobulins
- 3 January 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 163 (3862) , 75-78
- https://doi.org/10.1126/science.163.3862.75
Abstract
The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human γM-globulin is homologous to the NH 2 -terminal sequences of the gamma-chain of human and rabbit γG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.Keywords
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