Application Op Analogue Computations to Dissolution Model Development

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Abstract
Analogue computations of the influence of variable experimental parameters on the dissolution kinetics of a drug have been applied to the development and programming of a flow-through type dissolution model. The investigations have been performed with non-formulated Phenylbutazone capsules. The analogue computations revealed definite values for a pH-time-profile and an in-vitro-absorption rate constant, if the simulations were related to in vivo-data. Thus, programming a dissolution device in this way the results meet both analogue computer simulation and in vivo-absorption kinetics.