In vitro synergism of FR-31564, a new phosphonic acid antibiotic.

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Abstract
Against most test strains of gram-negative bacilli, the in vitro effect of FR-31564 together with .beta.-lactam antibiotics or trimethoprim was strongly synergistic; with tetracycline and nalidixic acid the effect was additive; and with gentamicin and sulfamethoxazole the effect was additive or antagonistic. FR-31564 was markedly synergistic with .beta.-lactam antibiotics against .beta.-lactam antibiotic-resistant gram-negative bacilli such as Klebsiella pneumoniae, Enterobacter aerogenes, E. cloacae, Citrobacter freundii and Serratia marcescens. The combination of FR-31564 with .beta.-lactam antibiotics effected a reduction of MICs [minimal inhibitory concentrations] against most of the test strains to clinically achievable concentrations in human serum.

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