Asymmetric Synthesis of the Enantiopure C28-C41 Segment of the Phorboxazoles A and B
- 1 May 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1999 (05) , 797-802
- https://doi.org/10.1055/s-1999-3470
Abstract
The phorboxazoles A and B are a new class of biologically highly active macrolides. The enantiopure C28-C41 segment containing four stereogenic centers, an E-configurated trisubstituted double bond and the 2,4-difunctionalized oxazole moiety has been prepared in 16 steps in 10% overall yield. The synthesis represents advances in strategy and methodology.Keywords
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