INFERTILITY OF MICE INDUCED BY ANTIBODIES SPECIFIC FOR HUMAN CHORIONIC GONADOTROPHIN
- 1 April 1969
- journal article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 60 (4) , 681-688
- https://doi.org/10.1530/acta.0.0600681
Abstract
Injections of rabbit antisera to cross-linked human chorionic gonadotrophin (HCG) into female STu mice made tolerant to rabbit γ-globulin, induced prolonged oestrus lasting for 18–60 days and phases of sterility of 37–130 days duration. When immune-competent mice were treated in a similar manner these effects were very markedly decreased due to the interference of antibodies developed against rabbit serum proteins. The results are discussed on the basis of cross-reactions with endogenous gonadotrophins.Keywords
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