Molecular Epidemiology of Haemophilus influenzae Type b Isolated from Children with Clinical Cases of Conjugate Vaccine Failures

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Abstract
We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti -H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.