Drosophila, the golden bug, emerges as a tool for human genetics
Top Cited Papers
- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 6 (1) , 9-23
- https://doi.org/10.1038/nrg1503
Abstract
Drosophila melanogaster is emerging as one of the most effective tools for analyzing the function of human disease genes, including those responsible for developmental and neurological disorders, cancer, cardiovascular disease, metabolic and storage diseases, and genes required for the function of the visual, auditory and immune systems. Flies have several experimental advantages, including their rapid life cycle and the large numbers of individuals that can be generated, which make them ideal for sophisticated genetic screens, and in future should aid the analysis of complex multigenic disorders. The general principles by which D. melanogaster can be used to understand human disease, together with several specific examples, are considered in this review.Keywords
This publication has 168 references indexed in Scilit:
- The International HapMap ProjectNature, 2003
- The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes ApoptosisCell, 2003
- GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5Nature, 2003
- salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell LinesCell, 2002
- Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of DeltaDevelopmental Cell, 2001
- Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1Nature Genetics, 1997
- De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndromeNature Genetics, 1997
- UBE3A/E6-AP mutations cause Angelman syndromeNature Genetics, 1997
- The gene lin-3 encodes an inductive signal for vulval development in C. elegansNature, 1992
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991