Polypeptides. Part XVII. The synthesis of some sequential polypeptides of γ-benzylD-glutamate andL-leucine
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 1, 5-12
- https://doi.org/10.1039/p19720000005
Abstract
The succinimidyl esters of mono-, di-, tri-, and tetra-γ-benzyl-D-glutamyl-L-leucine (VII; n= 1–4) have been prepared from the corresponding acids (V; n= 1–4), which were synthesised by the dicyclohexylcarbodi-imide method; the t-butoxycarbonyl group was used for amino-group protection and the 2-methylthioethyl ester group for carboxy-protection. Polymerisation of these esters gave satisfactory yields of the corresponding sequential polypeptides (I; n= 1–4) with molecular weights of between 11,000 and 31,000. Little racemisation (1–2%) accompanies the polymerisations, and the method is recommended as a procedure of choice for the synthesis of sequential polypeptides.Keywords
This publication has 0 references indexed in Scilit: