LPDE-Catalyzed Intramolecular Cyclization of Arylimines: A Facile Synthesis of Tetrahydrochromanoquinolines
- 1 June 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (06) , 0993-0995
- https://doi.org/10.1055/s-2002-31902
Abstract
Lithium perchlorate in diethyl ether (LPDE) is found to catalyze an intrarmolecular cyclization of aldimines derived from aromatic amines and O-prenyl derivatives of salicylaldehydes to afford the corresponding tetrahydrochromano[4,3-b]quinoline derivatives in excellent yields with moderate diastereoselectivity.Keywords
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