Complexity in Biological Signaling Systems
- 2 April 1999
- journal article
- special viewpoint
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 284 (5411) , 92-96
- https://doi.org/10.1126/science.284.5411.92
Abstract
Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.Keywords
This publication has 28 references indexed in Scilit:
- Emergent Properties of Networks of Biological Signaling PathwaysScience, 1999
- GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptorsNature, 1997
- Computing with cyclic AMPNature, 1996
- Excitation, oscillations and wave propagation in a G-protein-based model of signal transduction inDictyostelium discoideumPhilosophical Transactions Of The Royal Society B-Biological Sciences, 1995
- Memories of NMDA receptors and LTPTrends in Neurosciences, 1995
- Protein histidine kinases and signal tranduction in prokaryotes and eukaryotesTrends in Genetics, 1994
- Acetylcholinesterase density and turnover number at frog neuromuscular junctions, with modeling of their role in synaptic functionNeuron, 1994
- Calcium wavesCurrent Opinion in Neurobiology, 1993
- Inositol trisphosphate and calcium signallingNature, 1993
- Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclaseBiochemistry, 1979