Template-Directed Oligomerization Catalyzed by a Polynucleotide Analog
- 21 April 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4902) , 329-331
- https://doi.org/10.1126/science.2540527
Abstract
A pyrophosphate-linked analog of polycytidylic acid has been synthesized and shown to catalyze the oligomerization of the complementary monomer 2''-deoxyguanosine 3'',5''-bisphosphoimidazolide. Analogs of polynucleotides are of interest in studies of the origins of life as possible precursors of the first RNA molecules. These results demonstrate that such molecules are capable fo serving as templates for further synthesis.Keywords
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