Biotransformation, a new approach to aminoglycoside biosynthesis. II. Gentamicin.
- 1 January 1976
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (2) , 140-146
- https://doi.org/10.7164/antibiotics.29.140
Abstract
Utilizing a paromamine-producing mutant of Micromonospora purpurea blocked in the production of gentamicin, bioconversion of various minor gentamicin components into the gentamicin C complex was demonstrated. The compounds tested were structurally related to the gentamicin C's and are found as minor components in the gentamicin fermentation. Based upon the bioconversions detected, a branched pathway for the biosynthesis of the gentamicin C components is proposed.Keywords
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