Characterization of the LH Response to Luteinizing Hormone-Releasing Hormone (LH-RH) in Isolated and Multiple Tropic Hormone Deficiencies
- 1 December 1973
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 37 (6) , 972-976
- https://doi.org/10.1210/jcem-37-6-972
Abstract
Synthetic LH-RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time-course (peak at 30 min after the injection). When LH-RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH-RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mlU/ml to 10.8 mlU/ml (case one) and 2.5 mlU/ml to 8.3 mlU/ml (case two). The absence of a significant response after a single injection of LH-RH could be the result of chronic deprivation of LH-RH due to a hypothalamic lesion in these patients.Keywords
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