Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells
- 1 August 1990
- journal article
- research article
- Published by Springer Nature in Inflammation
- Vol. 14 (4) , 401-408
- https://doi.org/10.1007/bf00914091
Abstract
Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.This publication has 33 references indexed in Scilit:
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