Epinephrine v Thrombin for Split-Thickness Donor Site Hemostasis

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Abstract
Control of hemorrhage from donor sites should be rapid, effective, low in cost, and without systemic consequences. A prospective randomized study was conducted to compare the efficacy of topical thrombin (100 units/mL) and epinephrine (1:200,000) solutions. Each donor site was its own control. After skin harvest, but before treatment, bleeding was uniform in all areas of the donor site in 27 of 32 cases. After treatment, the epinephrine solution allowed less bleeding than the thrombin solution in 29 of 32 cases. In no instance was there less bleeding from a thrombin-treated area than from an epinephrine-treated one. No difference was noted in three cases. No systemic elevation of blood pressure and heart rate was noted. Epinephrine solution is an effective, safe, and inexpensive way to achieve hemostasis on split-thickness donor sites.

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