Significance of surgical adjuvant chemotherapy for gastric cancer
- 1 March 1991
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 46 (3) , 203-207
- https://doi.org/10.1002/jso.2930460316
Abstract
One hundred and twenty‐four specimens (72 primaries and 52 metastases) in 107 patients with gastric cancer were tested using the human tumor clonogenic assay (HTCA). Assays for 64 specimens (52%, 33 primaries and 31 metastases) were considered evaluable. The clonogenicity of the primaries was less than that of the metastases (P < 0.01). In the primary specimens, well‐differentiated tumors were more highly clonogenic than poorly differentiated or signet ring cell tumors (P < 0.05). Viable malignant cells and clonogenic cells were abundant in the primary tumors with mucosal (m) and submucosal (sm) invasion, i.e., in early gastric cancers by Japanese criteria, and were reduced in numbers as the primary tumors advanced (P0.05). In vitro chemosensitivity corresponded well to the clonogenicity of the primary tumors stratified by the degree of tumor invasion. At the early phase of primary tumor progression and metastasis, clonogenicity and chemosensitivity were high. Aggressive chemotherapy with sensitive drugs after surgery may improve the clinical results for the gastric cancer patients with early phase of metastases.Keywords
This publication has 12 references indexed in Scilit:
- Colony‐forming Ability in vitro and Clonology of Colorectal CancerJapanese Journal of Cancer Research, 1990
- Colony forming ability of human breast carcinomas: lack of prognostic significanceBritish Journal of Cancer, 1989
- Human tumor cloning assays: Applications in clinical oncology and new antineoplastic agent developmentCancer and Metastasis Reviews, 1988
- Soft agarose culture human tumour colony forming assay for drug sensitivity testing: [3H]-thymidine incorporation vs colony countingBritish Journal of Cancer, 1985
- Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlationsCancer, 1984
- A Critical Appraisal of the Human Tumor Stem-Cell AssayNew England Journal of Medicine, 1983
- Pharmacologic studies of anticancer drugs with the human tumor stem cell assayCancer Chemotherapy and Pharmacology, 1981
- Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer DrugsNew England Journal of Medicine, 1978
- Primary Bioassay of Human Tumor Stem CellsScience, 1977